The role of BRG1 in epigenetic regulation of cardiovascular diseases

作者：Ma, Zi-Yue; Li, Jing; Dong, Xian-Hui; Cui, Ying-Tao; Cui, Yun-Feng; Ban, Tao; Huo, Rong^*

来源：European Journal of Pharmacology, 2023, 957: 176039.

DOI：10.1016/j.ejphar.2023.176039

• BRG1
• Epigenetic regulator
• Cardiovascular disease

Cardiovascular diseases have been closely linked to abnormal epigenetic regulation. In the context of epigenetic regulation, BRG1, a pivotal SWI/SNF chromatin remodeling enzyme, emerges as a key epigenetic regulator with significant impact on the development and progression of cardiovascular disorders. From the perspective of epigenetic regulation of cardiovascular diseases, BRG1 emerges as a pivotal SWI/SNF chromatin remodeling enzyme, functioning as a key epigenetic regulator. It exerts substantial influence on the development and progression of cardiovascular disorders by exerting precise control over gene expression and protein levels. Therefore, a comprehensive understanding of BRG1's epigenetic regulatory role in cardiovascular disease is essential for unraveling its underlying pathophysiological mechanisms. This paper summarizes and discusses the function of BRG1 in the epigenetic regulation of cardiovascular diseases.

• 单位
  哈尔滨医科大学