Repression of CRNDE enhances the anti-tumour activity of CD8+T cells against oral squamous cell carcinoma through regulating miR-545-5p and TIM-3

作者：Ai, Yilong; Wu, Siyuan; Gao, Hai; Wei, Haigang; Tang, Zhe; Li, Xia^*; Zou, Chen^*

来源：Journal of Cellular and Molecular Medicine, 2021, 25(23): 10857-10868.

DOI：10.1111/jcmm.16909

• CRNDE
• immune response
• miR-545-5p
• OSCC
• TIM-3

Immunotherapy has been identified a promising treatment of cancers, including Oral squamous cell carcinoma (OSCC). CRNDE is highly overexpressed in various cancers. Many lncRNAs have been reported in CD8 T lymphocytes. Little is investigated about their effects in the functions of CD8 + T cells in OSCC. Currently, the influence of lncRNA CRNDE on the function of CD8 + T cells in OSCC progression was investigated. Here, CRNDE was obviously elevated and negatively correlated with IFN-gamma production in tumour-infiltrating CD8 + T cells isolated from OSCC patients. CRNDE can exhibit a crucial role in activating CD8 + T-cell exhaustion. Mechanistically, CRNDE specifically sponged miR-545-5p to induce T-cell immunoglobulin and mucin domain-3 (TIM-3), thus contributing to CD8 + T-cell exhaustion. The function of miR-545-5p on T-cell function remains poorly known. TIM-3 is a significant immune checkpoint, and it inhibits cancer immunity. TIM-3 can demonstrate an important role in CD8 + T-cell exhaustion. In summary, loss of CRNDE could induce miR-545-5p and inhibit TIM3 expression, thus significantly activated the anti-tumour effect of CD8 + T cells.

• 单位
  南方医科大学; 佛山科学技术学院