Synthesis of a novel thiophene derivative that induces cancer cell apoptosis through modulation of AKT and MAPK pathways

Authors：Luo Yi; Li Xiaoling; Chen Tianfeng^*; Wang Yi; Zheng Wenjie

Source：MEDCHEMCOMM, 2012, 3(9): 1143-1146.

DOI：10.1039/c2md20041d

A novel thiophene-based compound N-(4'-hydroxyphenyl)-2,5-di(2 ''-thienyl)pyrrole (SNS-OH) has been synthesized and evaluated for its in vitro anticancer activities. The results showed SNS-OH effectively induced apoptosis in neuroblastoma cells through regulating the AKT and MAPK pathways.

• Institution
  University of Jinan; Jinan University