High-sensitivity copper(II) sensor based on a protein/ion-imprinted polymer cooperative recognition strategy

作者：Zhang, Lianming^*; Li, Dan; Li, Shuhuai^*; Li, Jianping; Ma, Xionghui; Wang, Mingyue

来源：Microchemical Journal, 2023, 185: 108285.

DOI：10.1016/j.microc.2022.108285

• Dual recognition
• Bovine serum albumin
• Ion-imprinted polymer
• Cu2+
• Sensor

Despite the promise of ion imprinting technology for the development of electrochemical sensors for heavy metals, improved selectivity and stability are required for practical applications. Herein, a dual recognition strategy based on a protein and an ion-imprinted polymer (IIP) was proposed to develop highly sensitive sensors for copper(II) ions (Cu2+). On Bovine serum albumin (BSA) and graphene oxide (GO)-loaded gold nanoparticles (GO/Au NPs) modify the gold electrode surface, an a Cu2+ IIP was formed on the electrode by electro-polymerization. After Cu2+ was removed from IIP, the imprinted holes with a specific recognition ability for Cu2+ were obtained. In the prepared sensor, Cu2+ recognition sites were present in both BSA and the IIP, thus providing a dual recognition strategy for selective Cu2+ detection. Furthermore, owing to the amplification effect of GO/Au NPs, the sensor showed high sensitivity. With potassium ferricyanide/potassium ferrocyanide as a probe, the logarithm of the Cu2+ concentration was proportional to the sensor current response within the range of 1-8000 x 10-14 mol/L, and the detection limit was 1.12 x 10-15 mol/L. Moreover, for Cu2+ detection in actual samples, the sensor exhibited a recovery rate of 93.2-105.6 %.

• 单位
  test; 桂林理工大学; TEST; 中国科学院