Iodinene Nanosheet-to-Iodine Molecule Allotropic Transformation for Antibiosis

作者：You, Yanling; Zhu, Ya-Xuan; Jiang, Junjie; Chen, Zhixin; Wu, Chenyao; Zhang, Zhimin; Lin, Han^*; Shi, Jianlin^*

来源：Journal of the American Chemical Society, 2023, 145(24): 13249-13260.

DOI：10.1021/jacs.3c02669

• HYDROGEN-PEROXIDE
• POVIDONE-IODINE
• NANOPARTICLES

Iodine,as a typical haloid element in group VIIA, has been extensivelyapplied as antiseptics clinically, thanks to its effective and wide-spectrumantimicrobial activity against bacteria, fungi, and viruses. Nevertheless,current iodic sterilizing agents are still limited to topical applicationssuch as instrument sterilization and treatments of skin or mucousmembrane infection due to its unsatisfactory stability and biocompatibility.Here, we propose an emerging two-dimensional iodine nanomaterial (notedas iodinene) for the treatment of infection diseases in vivo. Iodinene nanosheets were fabricated by a facile and environmentallyfriendly approach via sonication-assisted liquid exfoliation, whichpresent an intriguing layered structure and negligible toxicity. Theas-synthesized iodinene would experience an in situ allotropic transformation spontaneously to release active HIO andI(2) molecules by reacting with H2O2 in the infectious microenvironment. By the in situ production of active HIO and I-2 molecules via allotropictransformation, iodinene presents enhanced antibacterial efficacyagainst Staphylococcus aureus, Escherichiacoli, and Pseudomonas aeruginosa. In vivo outcome demonstrates the desirable antibacterialefficacy of iodinene in treating bacterial wound infection and pneumonia.This study thus offers an alternative to conventional sterilizingagents against hard-to-treat bacterial infections.

• 单位
  同济大学; 中国科学院; 中国医学科学院; 中国科学院研究生院