Access to Amino Lactones through Palladium-Catalyzed Oxyamination with Aromatic Amines as the Nitrogen Source

作者：Liu, Chao; Wu, Jiahao; Tan, Xiangwen; Zhang, Jinhui; Wu, Wanqing; Jiang, Huanfeng^*

来源：ACS Catalysis, 2023, 13(17): 11339-11344.

DOI：10.1021/acscatal.3c02864

• palladium
• aromatic amine
• oxyamidation
• amino lactone
• dyotropic rearrangement

Although the synthesis of amino lactones with variousnitrogensources has achieved great success, variants focused on aromatic aminecounterparts still remain elusive. Herein, we communicate the intermolecularoxyamination reaction of aromatic amines and unactivated alkenyl carbonylcompounds under palladium catalysis. In the reaction, both primaryand second aromatic amines yield the corresponding & beta;-arylamino-& gamma;-lactonesefficiently. A key step in this process involves a Pd-II/Pd-IV catalytic cycle incorporating a 1,2-(C-N)/(C-O)dyotropic rearrangement. This reaction demonstrates mild reactionconditions and good functional group compatibility.