D-π-A structure fluorophore: NIR emission, response to viscosity, detection cyanide and bioimaging of lipid droplets

作者：Liu, Chuang; Zhang, Di; Ye, Sheng; Chen, Tong^*; Liu, Ruiyuan^*

来源：Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy , 2022, 267: 120593.

DOI：10.1016/j.saa.2021.120593

• NIR fluorescence
• Response to viscosity
• Cyanide detection
• Lipid droplets imaging

Intracellular viscosity, an important microenvironment factor, is closely involved in various cell processes as well as diseases. On the other hand, cyanide is one of the most hazardous chemicals for human health and environments. However, a NIR fluorescent probe for both response to viscosity and detection of cya-nide remains vacant. Herein, we reported a D -p-A structure fluorophore (named CTR) which exhibited NIR emission and fluorescent enhancement response to viscosity via the molecular rotor strategy. Furthermore, CTR displayed fluorescent and colorimetric response to cyanide. Notably, test strips stained with CTR were fabricated, which could serve as an efficient and suitable cyanide test kit. Moreover, CTR could selectively accumulate in lipid droplets and visualize the metabolism of lipid droplets in live cells. These findings would provide new avenue to design fluorescent probe for effective response to viscosity, detection of cyanide, and bioimaging of lipid droplets in live cells.

• 单位
  南方医科大学