Cobalt-Tertiary Amine Mediated Peroxy-trifluoromethylation and -halodifluoromethylation of Alkenes with CF2XBr (X = F, Cl, Br) and tert-Butyl Hydroperoxide

作者：Pang, Liangzhi; Sun, Qilin; Huang, Zhan; Li, Suhua^*; Li, Qiankun^*

来源：Synthesis, 2022, 54(09): 2193-2204.

DOI：10.1055/a-1702-4445

• trifluoromethylation
• chlorodifluoromethylation
• bromo-difluoromethylation
• peroxyl
• cobalt

An efficient cobalt-tertiary amine mediated peroxy-trifluoromethylation and -halodifluoromethylation of alkenes with simple and inexpensive CF2XBr (X = F, CI, Br) has been described. This method demonstrated broad substrate scope and good to high yields with the tolerance of mono-, di-, and trisubstituted alkenes with both electron-donating and electron-withdrawing groups. The protocol provides an efficient access to various beta-peroxyl trifluoromethyl/halodifluoromethyl derivatives. Further transformation of these type of compounds into other useful molecules, such as a ketene aminal, an alpha-trifluoromethyl ketone, and a gem-difluoroalkene, demonstrated the utility of this methodology.

• 单位
  中山大学