Antimicrobial mexicanolide limonoids from the seeds of Khaya senegalensis

作者:Jiang, Yue-Hong; Jiang, Ting-Jun; Lv, Xiao-Feng; Yu, Xiao-Fei; Chi, Wei-Qun*
来源:JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2022, 24(7): 634-640.
DOI:10.1080/10286020.2021.1972981

摘要

Three new mexicanolide limonoids were obtained from the 90% ethanol extract of the seeds of Khaya senegalensis. Their structures were elucidated as senegalenines A-C (1-3) by analysing their 1D/2D NMR and MS spectroscopic analysis. In addition, the isolated limonoids were tested in vitro for antimicrobial potentials against 5 pathogenic microorganisms. Consequently, compounds 1-3 exhibited antimicrobial activity against the tested Gram negative bacteria at the minimum inhibitory concentration values less than 40 mu g/ml.

  • 单位
    哈尔滨医科大学