小P值并不能保证可靠结果：以帕金森病的静息态脑功能成像元分析为例（英文）

作者：贾熙泽; 赵娜; 董昊铭; 孙家伟; Marek Barton; Roxana Burciu; Nicolas Carrière; Antonio Cerasa; 陈博宇; 陈俊; Stephen Coombes; Luc Defebvre; Christine Delmaire; Kathy Dujardin; Fabrizio Esposito; 范国光; Federica Di Nardo; 冯怡萱; Brett W.Fling; Saurabh Garg; Moran Gilat; Martin Gorges; Shu-Leong Ho; Fay B.Horak; 胡晓; 胡晓飞; 黄飚; 黄沛钰; 贾泽娟; Christina Jones; Jan Kassubek; Lenka Krajcovicova; Ajay Kurani; 李静; 李晴; 刘爱萍; 刘波; 刘虎; 刘卫国; Renaud Lopes; 娄毓婷; 罗巍; Tara Madhyastha; 毛妮妮; Grainne McAlonan; Martin J.McKeown; Shirley Pang

来源：Science Bulletin, 2021, 66(21): 2148-2152.

• 元分析
• 静息态脑功能成像
• 帕金森病

<正>Thousands of resting state functional magnetic resonance imaging (RS-f MRI) articles have been published on brain disorders. For precise localization of abnormal brain activity, a voxel-level comparison is needed. Because of the large number of voxels in the brain, multiple comparison correction (MCC) must be performed to reduce false positive rates, and a smaller P value (usually including either liberal or stringent MCC) is widely recommended [1].

• 单位
  The University of Hong Kong; NORTHWESTERN UNIVERSITY; NorthwesternUniversity; the University of Hong Kong; the University of Washington; 四川大学; Oregon Health & Science University; Oregon Health and Science University; NorthWestern University; Feinberg School of Medicine; National Institutes of Health; Ulm University; University of washington; The University of Hongkong; 浙江大学; 杭州师范大学; University of Salerno; The University of Sydney; The Mind Research Network