Metal-Free Catalyzed Defluorinative O -Arylation of Pyrazolones with Polyfluoroarenes

摘要

An efficient and general method for defluorinative O-aryla-tion of pyrazolones has been successfully developed under metal-free conditions. This methodology allows for the synthesis of desired prod-ucts by using a wide range of pyrazolones and polyfluoroarenes as starting materials. The compatibility of various substrates was demon-strated, ensuring the applicability of this method. Furthermore, the synthesis of the target compounds at a gram scale and the ability to perform late-stage modifications highlight the potential of this ap-proach in preparative pharmaceutical synthesis and organofluorine chemistry.

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