Two new α-pyrone-containing polyketides isolated from the fungus Aspergillus aureoterreus

摘要

Two undescribed alpha-pyrone-containing polyketide derivatives designated aurovertins V (1) and W (2), and a known analogue (3), were isolated from the fungus Aspergillus aureoterreus. Their structures including the absolute configuration were elucidated on the basis of extensive spectroscopic methods and theoretical ECD calculation. Compound 1 is the first example of aurovertins with a 7R configuration, whereas 2 comprises a S configuration for C-6 and a Z geometry of the double bond Delta(8) . Both 1 and 2 showed no cytotoxicity against human cancer cell lines HL-60, SU-DHL-2 and U266) at the concentration of 20.0 mu M.

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