Green synthesis of δ-lactam from biomass-derived 4-hydroxy-6-methylpyridin-2(1H)-one

作者：Wang, Yaqin; Chen, Bingfeng^*; Wu, Haihong^*; Mei, Xuelei; Zhang, Kaili; Zheng, Bingxiao; Han, Wanying; Xu, Jiao; He, Mingyuan; Han, Buxing^*

来源：Green Chemistry, 2023, 25(5): 1835-1841.

DOI：10.1039/d2gc04382c

• TRIACETIC ACID LACTONE
• CATALYTIC TRANSFER HYDROGENATION
• CYCLIC AMINES
• MECHANISTIC INSIGHTS
• 4-HYDROXY-6-METHYL-2-PYRONE
• OXIDATION
• 2-PYRONES
• PATHWAY
• WATER

Hydrodeoxygenation is usually an essential step for biomass valorization owing to its highly oxygenated nature, and the catalytic transfer hydrogenation provides a promising alternative for hydrodeoxygenation of biomass feedstocks because of its feasibility and safety. Herein, a novel and sustainable route for delta-lactam production, which was previously produced from non-renewable fossil raw materials via stoichiometric reactions or catalytic reactions, has been demonstrated through catalytic transfer hydrogenation/hydrogenolysis of 4-hydroxy-6-methylpyridin-2(1H)-one (HMPO), which can be easily obtained from biomass-derived triacetic acid lactone (TAL). The Ni-Ru bimetallic catalysts supported on a carbon support had excellent catalytic performance, and the desired product could reach 83.5%, which was much higher than that obtained from other bimetallic or monometallic catalysts and superior to commercial catalysts. The Ru-0/RuOx ratios, which can be tuned by the introduction of Ni species in the bimetallic catalysts, played a crucial role in the catalytic system. The Ni-Ru/C catalyst also exhibited good catalytic recyclability.

• 单位
  中国科学院