Recent advances in cellular optogenetics for photomedicine

作者：Chen, Bing; Cui, Meihui; Wang, Yuan; Shi, Peng^*; Wang, Hanjie^*; Wang, Feng^*

来源：Advanced Drug Delivery Reviews, 2022, 188: 114457.

DOI：10.1016/j.addr.2022.114457

• Optogenetic tools
• Light delivery
• Neuronal regulation
• Signaling pathways
• Phototherapy

Since the successful introduction of exogenous photosensitive proteins, channelrhodopsin, to neurons, optogenetics has enabled substantial understanding of profound brain function by selectively manipulat- ing neural circuits. In an optogenetic system, optical stimulation can be precisely delivered to brain tissue to achieve regulation of cellular electrical activity with unprecedented spatio-temporal resolution in liv- ing organisms. In recent years, the development of various optical actuators and novel light-delivery techniques has greatly expanded the scope of optogenetics, enabling the control of other signal pathways in non-neuronal cells for different biomedical applications, such as phototherapy and immunotherapy. This review focuses on the recent advances in optogenetic regulation of cellular activities for pho- tomedicine. We discuss emerging optogenetic tools and light-delivery platforms, along with a survey of optogenetic execution in mammalian and microbial cells.

• 单位
  天津大学