Novel biodegradable two-dimensional vanadene augmented photoelectro-fenton process for cancer catalytic therapy

作者：Nie, Yichu; Zhang, Weilang; Xiao, Wenqing; Zeng, Weiwei^*; Chen, Ting; Huang, Weiqiang; Wu, Xixi; Kang, Yong; Dong, Jinrui; Luo, Wei^*; Ji, Xiaoyuan^*

来源：Biomaterials, 2022, 289: 121791.

DOI：10.1016/j.biomaterials.2022.121791

• Vanadene
• Two-dimensional nanomaterials
• Fenton reaction
• Chemodynamic therapy
• Photodynamic therapy

Fenton reaction-based chemodynamic therapy is hardly a self-sufficient cancer treatment, due to its stringent reaction conditions, limited substrate concentration, and negative feedback from the tumor microenvironment. Herein, we synthesized a novel two-dimensional (2D) vanadium-based nanosheets (Vanadene, V NSs) with polyvalent surfaces (V-IV/V-V), a very narrow band gap of 0.8 eV, and high biodegradability by a liquid-phase exfoliation strategy. The polyvalent surface endowed its multiple capabilities to modulate TME through GSH consumption and O-2 production via V(V )and to catalyze a Fenton-like reaction to produce center dot OH under a mild condition via V-IV. In addition, efficient energy conversions including near-infrared (NIR)-thermal conversion (photothermal therapy, PTT) and NIR-electron conversion (photodynamic therapy, PDT) were ensured by the narrow band gap, in which NIR-thermal conversion enhanced the Fenton-like reaction activity through accelerating ionization while NIR-electron conversion catalyzed the conversion of O-2 to center dot O-2(-) for further breaking redox homeostasis. Moreover, V NSs-based nanocatalyst can be slowly degraded into non-toxic species, enabling it to be innocuously eliminated from the body after completing tumor eradication by single drug injection and single NIR irradiation. Therefore, this study provides new insights into a universal nanoplatform for NIR-enhanced combination cancer therapy, highlighting the utility of 2D V NSs in the field of biomedicine.

• 单位
  南方医科大学; 佛山市第一人民医院; 中国医学科学院; 天津大学; 中国医学科学院北京协和医院