Effects of zinc/gallium dual doping on the physicochemical properties and cell response of 3D printed 13-tricalcium phosphate ceramic scaffolds

Authors：Wang, Yao; Yuan, Xinyuan; Ye, Jiandong; He, Fupo^*

Source：Ceramics International, 2022, 48(19): 28557-28564.

DOI：10.1016/j.ceramint.2022.06.169

• Ionic doping
• Calcium phosphate
• Ceramic scaffolds
• Bone generation
• Cell response

Ideal osteoporotic bone defect repair materials are capable of enhancing osteogenesis and simultaneously restraining osteoclastogenesis. Gallium has a potent effect on inhibiting osteoclastogenesis, but it cannot promote osteogenesis. Zinc is a well-documented osteostimulative element. In this work, zinc/gallium co-doped 13-tricalcium phosphate (ZG-TCP) ceramic blocks and scaffolds were prepared through mold forming and extrusiontype 3D printing technology, respectively. The zinc/gallium dual doping promoted densification of 13-tricalcium phosphate ceramics, thereby affecting the compressive strength. The ZG-TCP ceramic scaffolds showed 3D interconnected uniform pore structure. The zinc and gallium released from ZG-TCP compromised cell proliferation, increased the alkaline phosphatase activity of bone marrow stromal cells, and restrained the osteoclastogenesis of RAW264.7 cells. The ZG-TCP ceramic scaffolds doped with 0.5 mol% zinc and 2.5 mol% gallium possessed the most favorable comprehensive properties, including considerable compressive strength, enhanced osteoblastogenesis and suppressed osteoclastogenesis, so they are suitable for regenerating osteoporotic bone defects.

• Institution
  广东工业大学