Two-photon fluorescence imaging and ratiometric quantification of mitochondrial monoamine oxidase-A in neurons

作者：Mei, Yuxiao; Liu, Zhichao; Liu, Meijun; Gong, Jiacheng; He, Xiao; Zhang, Qi-Wei^*; Tian, Yang^*

来源：Chemical Communications, 2022, 58(46): 6657-6660.

DOI：10.1039/d2cc01909d

• PROBE

Herein, we designed and developed a single two-photon ratiometric fluorescence probe (TMF2P) for selective and accurate determination of mitochondrial MAO-A in live neurons. It was discovered that the increases in MAO-A levels under oxidative stress resulted in an elevated influx of Ca2+ flow into mitochondria through the transient receptor potential melastatin 2 (TRPM2) channels.

• 单位
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