Constructing lipid droplet-targeting photosensitizers based on coumarins with NIR emission

作者：Guo, Yimin; Liu, Weimen^*; Sha, Jie; Li, Xuewei; Ren, Haohui; Wu, Jiasheng; Zhang, Wenjun; Lee, Chun-Sing; Wang, Pengfei^*

来源：Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy , 2023, 296: 122698.

DOI：10.1016/j.saa.2023.122698

• Coumarin
• Near-infrared emission
• Lipid droplet-targeting
• Photodynamic effect
• Singlet-atom replacement

The development of photosensitizers (PSs) with subcellular targeting capability has raised interest for photodynamic therapy (PDT) research. In this work, two coumarin-based photosensitizers (C-S-2 and C-S-3) were designed and synthesized via expanding their & pi;-conjugation, introducing strong electron-donor and acceptor groups, and adopting sulfur substitution strategy. These sulfured-coumarins exhibited near-infrared emission (greater than 650 nm), lipid droplet-targeting ability and obvious photocytotoxicity under laser irradiation. In particular, C-S-3 exhibited better photostability, superior lipid droplet-targeting capability, and stronger photodynamic effect on cancer cells than C-S-2.

• 单位
  中国科学院研究生院