In Vitro Hypoglycemic Diterpenoids from the Roots of Croton yunnanensis

Authors：Jiang, Zhi-Yong^*; Liu, Chun-Jiang; Niu, Qi; Yan, Xin-Yu; Xiao, Die; Zhang, Hong-Lei; Huang, Chun-Qiu; Shi, Sheng-Li^*; Zuo, Ai-Xue^*; He, Hong-Ping^*

Source：Journal of Natural Products, 2023.

DOI：10.1021/acs.jnatprod.2c00970

• INDUCED INSULIN-RESISTANCE
• ALPHA
• ADIPOCYTES
• INHIBITION
• ANTIFUNGAL
• CLERODANE

Fifteen compounds including nine new diterpenes were isolated from the roots of Croton yunnanensis. By HRESIMS, NMR, ECD data, and X-ray diffraction analysis, the new compounds were characterized as eight neo-clerodane diterpenes (compounds 1-8) and one 15,16-dinor-ent-pimarane diterpene (9). All diterpenes were assayed for their hypoglycemic activities. Compounds 1-4, 6, 7, and 10 promoted glucose uptake activity in insulin-resistant 3T3-L1 adipocytes. Compounds 1 and 6 showed insulin sensitizing activity, potentiating conspicuously their glucose uptake activity at a concentration of 20 mu M when treated synergistically with low-concentration insulin at 1 nM.

• Institution
  云南大学