Discovery of Cyclic Diarylheptanoids as Inhibitors against Influenza A Virus from the Roots of Casuarina equisetifolia

作者：Xu, Xiaoyu; Chen, Liurong; Luo, Yucai; Gao, Ruanling; Xu, Yingting; Yang, Jie^*; Zhou, Zhongyu^*; Wei, Xiaoyi

来源：Journal of Natural Products, 2022.

DOI：10.1021/acs.jnatprod.2c00335

• CORYLUS-AVELLANA
• ANTIOXIDANT

Four new cyclic diarylheptanoids, casuarinols A-C (1-3) and casuarinolide A (4), together with six known ones (5- 10), were isolated from the roots of Casuarina equisetifolia. Structures were elucidated by extensive spectroscopic analysis, theoretical conformational, and electronic circular dichroism analyses. Casuarinol C (3) is a novel cyclic diarylheptanoid-aldehyde adduct. Casuarinolide A (4) represents the first structure of a seco-cyclic diarylheptanoid. Compounds 1-9 were evaluated for their anti influenza A virus (IAV) activity against A/WSN/33 (H1N1). (-)-(M)-11-Oxo-3,12R,17-trihydroxy-9-ene-[7,0]-metacyclophane (5) displayed significant anti-IAV activity with an IC50 value of 8.64 +/- 2.49 mu M and a CC50 higher than 100 mu M.

• 单位
  南方医科大学; 中国科学院研究生院