Synthesis of Highly Conjugated Functionalized 2-Pyridones by Palladium-Catalyzed Aerobic Oxidative Dicarbonation Reactions of N-(Furan-2-ylmethyl) Alkyne Amides and Alkenes as Coupling Partners

Authors：Yang, Yongjie; Jiang, Kai; Zhu, Hua; Yin, Biaolin^*

Source：Journal of Organic Chemistry, 2021, 86(3): 2748-2759.

DOI：10.1021/acs.joc.0c02730

A mild, step-economical method for the synthesis of highly conjugated functionalized 2-pyridones from N-(furan-2-ylmethyl) alkyne amides is reported. This method involves Pd-catalyzed aerobic oxidative dicarbonation reactions of alkynes with carbon nucleophiles of a furan ring and an acrylate or styrene as coupling partners. The UV-vis absorption spectra of some of the 2-pyridones indicated that they absorbed shortwave radiation, suggesting their potential utility for filtration of such radiation.