New iboga-type alkaloids from Ervatamia officinalis and their anti-inflammatory activity

作者：Tang, Ben-qin^*; Li, Zi-wei; Li, Lin; Li, Bao-jing; Bian, Ya-qi; Yu, Guo-dong; Chang, Yu; Lee, Simon Ming-yuen; Zhang, Xiao-qi^*

来源：FITOTERAPIA, 2022, 156: 105085.

DOI：10.1016/j.fitote.2021.105085

• Ervatamia officinalis
• Iboga-type alkaloids
• Anti-inflammatory
• Ervaoffines
• NO release

Four new iboga-type alkaloids, ervaoffines H-K (1-4), along with five known compounds were obtained from the aerial parts of Ervatamia officinalis. The absolute configurations of 1-4 were confirmed by X-ray diffraction and electronic circular dichroism (ECD) analyses. The isolates were tested for their anti-inflammatory activity. Compounds 1, 5, 6, and 9 showed potential inhibitory effect of NO production in LPS-stimulated BV2 and RAW264.7 cells.

• 单位
  云南大学