Levels of PAH-DNA adducts in placental tissue and the risk of fetal neural tube defects in a Chinese population

作者：Yuan Y; Jin L; Wang L; Li Z; Zhang L; Zhu H; Finnell R H; Zhou G; Ren A^*

来源：Reproductive Toxicology, 2013, 37: 70-75.

DOI：10.1016/j.reprotox.2013.01.008

• DNA adducts
• Fetus
• Neural tube defects (NTDs)
• Placenta
• Polycyclic aromatic hydrocarbons (PAHs)

We examined the relationship between PAH-DNA adduct levels in the placental tissue, measured by a highly sensitive 32P-postlabeling assay, and the risk of fetal neural tube defects (NTDs). We further explored the interaction between PAH-DNA adducts and placental PAHs with respect to NTD risk. Placental tissues from 80 NTD-affected pregnancies and 50 uncomplicated normal pregnancies were included in this case-control study. Levels of PAH-DNA adducts were lower in the NTD group (8.12 per 108 nucleotides) compared to controls (9.92 per 108 nucleotides). PAH-DNA adduct concentrations below the median was associated with a 3-fold increased NTD risk. Women with a low PAH-DNA adduct level in concert with a high placental PAH level resulted in a 10-fold elevated risk of having an NTD-complicated pregnancy. A low level of placental PAH-DNA adducts was associated with an increased risk of NTDs; this risk increased dramatically when a low adduct level was coupled with a high placental PAH concentration.

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  Texas A & M University; Texas A and M University; The University of Texas at Austin; TEXAS A&M University; TEXAS A&M UNIVERSITY; United States; Texas A&M university