Engineering air-in-water emulsion as adaptable multifunctional sealant

作者：Xu, Mingjian; Li, Qingtao; Xie, Manshan; Jia, Yong-Guang; Yang, Yu; Chen, Yunhua^*

来源：Chemical Engineering Journal, 2022, 429: 132200.

DOI：10.1016/j.cej.2021.132200

• NANOCOMPOSITE HYDROGELS
• ANTIBACTERIAL
• ADHESIVE
• DESIGN

Immediate hemorrhage control and wound closure play important roles in soft-tissue wound management. Developing adaptable sealant dressings with multifunctions to accelerate wound healing is highly demanded but remains challenging. In this study, we report a macmporous nano-enabled sealant based on gelatin methacryloyl stabilized air-in-water emulsions combined with Laponite nanoclays and poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT: PSS). The sealant demonstrates tunable pore size, robust mechanical properties, conductivity and wet-adhesiveness. Imparting macroporous structures and nanoclays, the biocompatible sealant could well support cell adhesion and proliferation, and reveal promising in vitro blood clotting ability as well as haemostatic performance in a rat liver lethal hemorrhage model in vivo. Furthermore, the results from a full-thickness skin defect model clearly demonstrate this conductive macroporous nano-enabled sealant could significantly promote granular tissue growth and collagen deposition thus accelerated wound healing process.

• 单位
  华南农业大学