Inhibition of alpha-glucosidase by polysaccharides from the fruit hull of Camellia oleifera Abel

作者：Zhang Sheng; Li Xiang Zhou^*

来源：Carbohydrate Polymers, 2015, 115: 38-43.

DOI：10.1016/j.carbpol.2014.08.059

• Polysaccharides
• Camellia oleifera Abel fruit hull
• alpha-Glucosidase inhibition

We isolated and purified polysaccharides from the Camellia oleifera Abel. fruit hull and studied its hypoglycemic potential. Our results revealed six polysaccharides (CFPA-1-5 & CFPB) from the aqueous extract from the defatted C. oleifera fruit hull. Purified polysaccharides (purity >90%) were investigated for the inhibition of alpha-glucosidase activity in vitro. Two polysaccharides, CFPB and CFPA-3 were present in high concentration in the fruit hull and showed a dose-dependent inhibition of alpha-glucosidase activity, with IC50 concentrations of 11.80 and 10.95 mu g/mL, respectively. This result suggests that polysaccharides( CFP) extracted from the fruit hull of C. oleifera may have potential as functional foods with featuring a hypoglycemic effect.