Rh(III)-Catalyzed Atroposelective C-H Iodination of 1-Aryl Isoquinolines

作者：Zheng, Dong-Song; Zhang, Wen-Wen; Gu, Qing^*; You, Shu-Li^*

来源：ACS Catalysis, 2023, 13(8): 5127-5134.

DOI：10.1021/acscatal.3c00751

• asymmetric catalysis
• axial chirality
• biaryl iodide
• C
• H iodination
• Rh-catalyzed

The rhodium-catalyzed enantioselective C-H iodination of 1-aryl isoquinolines under mild conditions is disclosed. Direct C-H iodination of 1-aryl isoquinolines with N-iodosuccinimide (NIS) catalyzed by chiral CpRh(III) complexes afforded a series of axially chiral biaryl iodides in excellent yields and enantioselectivity (up to 99% yield and 97% ee). Furthermore, the atroposelective C-H bromination and chlorination reactions were also compatible. Notably, the axially chiral biaryl iodides could be easily transformed to QUINAP-type and N,N-type chiral ligands.

• 单位
  中国科学院