Copper-Catalyzed Asymmetric Synthesis of Bicyclo[3.n.1]alkenones

作者：Liao, Zhehui; Zhang, Jiantao; Cao, Tongxiang^*; Zhu, Shifa^*

来源：Journal of Organic Chemistry, 2021, 86(7): 5388-5400.

DOI：10.1021/acs.joc.1c00146

• ALPHA-ARYLATIVE DESYMMETRIZATION
• ENANTIOSELECTIVE SYNTHESIS
• MICHAEL ADDITION
• CONSTRUCTION
• CYCLIZATION

A series of highly strained bicyclo[3.n.1]alkenones have been successfully constructed in good-to-excellent enantioselectivities and moderate-to-good yields via copper-catalyzed formal [3+3] cycloaddition. The versatile chiral cycloadducts could be selectively converted into various valuable bridge systems, which hold considerable potential for the construction of natural and bioactive compounds containing a [3.n.1] moiety.

• 单位
  茂名学院