Therapeutic effect of imatinib-loaded hydrogels on leukemia by inhibiting excessive apoptosis of white blood cells

作者：Zhang, Ying; Shen, Huijun; Shi, Wudan^*

来源：Materials Express, 2023, 13(3): 447-450.

DOI：10.1166/mex.2023.2363

• Chronic Myelocytic Leukemia
• Imatinib
• Hydrogels

Chronic myelocytic leukemia (CML) refers to a malignant proliferative disease of the bone marrow characterized by abnormalities of multipotent stem cells on the Philadelphia chromosome and accounts for approximately 20% of all leukemias. Imatinib is widely used in the treatment of CML patients because of its unique mechanism of action and high specificity. In this study, imatinib-loaded hydrogels were prepared from the natural polysaccharide hyaluronic acid and carboxymethyl chitosan. SEM results showed that the hydrogels IP: 203.8.109.20 On: Tue 13 Jun 2023 07:07:26 had a macroporous structure with inteconnected pores nside. CCK-8 reults indicated that the hydrogels Copyright: Amercan Scientific Publishers could significantly reduce the viability of leukocytes.In addition, the hydrogel increased the expression of Delivere by Ingenta BCL-2 with increasing dose and is promising to be used as a drug carrier material for leukemia treatment.

• 单位
  哈尔滨医科大学