The ATF2/miR-3913-5p/CREB5 axis is involved in the cell proliferation and metastasis of colorectal cancer

作者：Dai, Weiyu; Hong, Linjie; Xiao, Wushuang; Zhang, Luyu; Sha, Weihong; Yu, Zhen; Liu, Xuehua; Liu, Side; Xiao, Yizhi; Yang, Ping; Peng, Ying; Zhang, Jieming; Lin, Jianjiao; Wu, Xiaosheng; Tang, Weimei; Lin, Zhizhao; Xiang, Li; Li, Jiaying^*; Pei, Miaomiao^*; Wang, Jide^*

来源：Communications Biology, 2023, 6(1): 1026.

DOI：10.1038/s42003-023-05405-w

• DOWN-REGULATION
• POOR-PROGNOSIS
• UP-REGULATION
• MICRORNAS
• ATF2
• INVASION
• FAMILY

Various miRNAs have been shown to participate in the tumor progression and development of colorectal cancer (CRC). However, the role of miR-3913-5p in CRC are yet to be clearly defined. In the present study, we determine that miR-3913-5p is downregulated in CRC cell lines and CRC tissues. Exogenous miR-3913-5p expression weakens the CRC cells growth, migration and invasion. Mechanistically, miR-3913-5p directly targets the 3'UTR of CREB5. Overexpression of CREB5 reverses the suppression of CRC cells proliferation, migration and invasion induced by miR-3913-5p. Furthermore, ATF2 negatively regulates the transcription of miR-3913-5p by binding to its promoter. CREB5 can cooperate with ATF2. CREB5 is required for ATF2 in regulating miR-3913-5p. Finally, inverse correlations can be found between the expressions of miR-3913-5p and CREB5 or ATF2 in CRC tissues. Thus, a plausible mechanism of ATF2/miR-3913-5p/CREB5 axis regulating CRC progression is elucidated. Our findings suggest that miR-3913-5p functions as a tumor suppressor in CRC. ATF2/miR-3913-5p/CREB5 axis might be a potential therapeutic target against CRC progression. @@@ The miRNA miR-3913-5p inhibits colorectal cancer cell proliferation, migration and invasion, in concert with its regulation of and by CREB5 and ATF2.

• 单位
  Southern Medical University; Guangdong General Hospital; 5; Fourth Military Medical University, Chinese People's Liberation Army; 1; Sun Yat-sen University; Guangzhou Medical University