Hydrogen-Bonded Organic Frameworks Chelated Manganese for Precise Magnetic Resonance Imaging Diagnosis of Cancers

Authors：Ouyang, Sixue; Chen, Chuyao; Lin, Peiru; Wu, Wanjia; Chen, Guanjun; Li, Pengfei; Sun, Mingyan; Chen, Huiting; Zheng, Zhiyuan; You, Yuanyuan; Lv, Sike; Zhao, Peng^*; Lin, Bingquan^*; Tao, Jia^*

Source：Nano Letters, 2023, 23(18): 8628-8636.

DOI：10.1021/acs.nanolett.3c02466

• hydrogen-bonded organic frameworks
• magnetic resonanceimaging
• contrast agent
• breast cancer
• orthotopic glioma

Magnetic resonance imaging (MRI) is an important tool in the diagnosis of many cancers. However, clinical gadolinium (Gd)-based MRI contrast agents have limitations, such as large doses and potential side effects. To address these issues, we developed a hydrogen-bonded organic framework-based MRI contrast agent (PFC-73-Mn). Due to the hydrogen-bonded interaction of water molecules and the restricted rotation of manganese ions, PFC-73-Mn exhibits high longitudinal relaxation r1 (5.03 mM(-1) s(-1)) under a 3.0 T clinical MRI scanner. A smaller intravenous dose (8 mu mol of Mn/ kg) of PFC-73-Mn can provide strong contrast and accurate diagnosis in multiple kinds of cancers, including breast tumor and ultrasmall orthotopic glioma. PFC-73-Mn represents a prospective new approach in tumor imaging, especially in early-stage cancer.

• Institution
  南方医科大学