Iron-Catalyzed and Air-Mediated C(sp3)-H Phosphorylation of 1,3-Dicarbonyl Compounds Involving C-C Bond Cleavage

作者：Ou, Yingcong; Huang, Yuanting; Liu, Yu; Huo, Yanping; Gao, Yang; Li, Xianwei; Chen, Qian^*

来源：Advanced Synthesis and Catalysis, 2020, 362(24): 5783-5787.

DOI：10.1002/adsc.202001020

• Phosphorylation
• C(sp(3))&#8722
• H bonds
• iron catalysts
• air
• &#946
• -ketophosphine oxides

A C(sp(3))-H phosphorylation has been achieved via the iron-catalyzed cross-coupling reactions between 1,3-dicarbonyl compounds and P(O)-H compounds involving C-C bond cleavages with air as the oxidant. This transformation provides a straightforward way to construct C(sp(3))-P bonds, leading to the formation of beta-ketophosphine oxides in up to 93% yield with good functional group tolerance.

• 单位
  广东工业大学