Mapping cryptic binding sites of drug targets to overcome drug resistance

作者：Gao, Yang-Yang; Yang, Wei-Cheng; Ashby Jr, Charles R.; Hao, Ge-Fei^*

来源：DRUG RESISTANCE UPDATES, 2023, 67: 100934.

DOI：10.1016/j.drup.2023.100934

• Drug resistance
• Cryptic binding sites
• Resistance management

The emergence of drug resistance is a primary obstacle for successful chemotherapy. Drugs that target cryptic binding sites (CBSs) represent a novel strategy for overcoming drug resistance. In this short communication, we explain and discuss how the discovery of CBSs and their inhibitors can overcome drug resistance.

• 单位
  贵州大学