Correlation of the occurrence of YMDD mutations with HBV genotypes,HBV-DNA levels,and HBeAg status in Chinese patients with chronic hepatitis B during lamivudine treatment

作者：Feng Wu; Min Jin Wu; Xiao Lin Zhuge; Shao Ming Zhu; Biao Zhu Department of Chinese Pharmacy; Department of Laboratory Medicine; State Key Laboratory for Diagnosis; Treatment of Infectious Diseases; First Affiliated Hospital; Zhejiang University School of Medicine; Hangzhou; China

来源：HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL, 2012, (02): 172-176.

• YMDD mutations
• lamivudine therapy
• chronic hepatitis B
• HBV genotype

BACKGROUND:Continuous lamivudine therapy is associated with high rates of YMDD mutations,which are the main causes of drug resistance.The current study explores the association of the emergence of YMDD mutations with pretherapy HBV genotype,HBV-DNA levels,HBeAg status,and serum alanine aminotransferase(ALT) levels in Chinese patients receiving lamivudine therapy for chronic hepatitis B.METHODS:A total of 319 chronic hepatitis B patients who received lamivudine therapy for more than a year were enrolled in t...