Remote Selective C-H Halogenation of Arylphosphine Oxides with Ferric Halides

作者：Yu, Hong; Lin, Xiuhua; Xu, Guang; Yin, Tingrui; Zhang, Ying; Liu, Jinpeng; Chen, Jian; Meng, Sixuan; Yuan, Jia^*; Dang, Li^*; Yu, Guang-Ao^*

来源：Advanced Synthesis and Catalysis, 2023.

DOI：10.1002/adsc.202300486

• Aryl phosphine oxides
• Bromination
• Chlorination
• Ferric halides
• C-H activation

We developed the remote selective C-H bromination for the synthesis of C4 & PRIME;-brominated biarylphosphine oxides using FeBr3 as a brominating reagent. C3 & PRIME;-Brominated products were obtained in reactions with substrates bearing a 2,4,6-triisopropyl substituent on the bottom ring. Moreover, direct access to C5-chlorinated peri-substituted(1-naphthalenyl)phosphines is developed using FeCl3 as a chlorinating reagent. These halogenated compounds can be utilized for cross-coupling reactions to construct functionalized phosphine oxides.

• 单位
  汕头大学