Research Progress of Nanomedicine-Based Mild Photothermal Therapy in Tumor

作者：He, Xiang; Zhang, Shentao; Tian, Yuhang; Cheng, Wen^*; Jing, Hui^*

来源：International Journal of Nanomedicine, 2023, 18: 1433-1468.

DOI：10.2147/IJN.S405020

• nanomedicine
• nanotechnology
• mild photothermal therapy
• tumor therapy

With the booming development of nanomedicine, mild photothermal therapy (mPTT, 42-45 degrees C) has exhibited promising potential in tumor therapy. Compared with traditional PTT (>50 degrees C), mPTT has less side effects and better biological effects conducive to tumor treatment, such as loosening the dense structure in tumor tissues, enhancing blood perfusion, and improving the immuno-suppressive microenvironment. However, such a relatively low temperature cannot allow mPTT to completely eradicate tumors, and therefore, substantial efforts have been conducted to optimize the application of mPTT in tumor therapy. This review extensively summarizes the latest advances of mPTT, including two sections: (1) taking mPTT as a leading role to maximize its effect by blocking the cell defense mechanisms, and (2) regarding mPTT as a supporting role to assist other therapies to achieve synergistic antitumor curative effect. Meanwhile, the special characteristics and imaging capabilities of nanoplatforms applied in various therapies are discussed. At last, this paper puts forward the bottlenecks and challenges in the current research path of mPTT, and possible solutions and research directions in future are proposed correspondingly.

• 单位
  哈尔滨医科大学