Aminoquinoline-anchored polynorbornene for sequential fluorescent sensing of Zn2+ and ATP

作者：Chen, Gui-Yan; Wan, Wen; Cao, Qian-Yong^*; Xie, Yu^*

来源：Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy , 2022, 269: 120771.

DOI：10.1016/j.saa.2021.120771

• Polynorbornene
• Ratiometric fluorescent sensor
• Zn2+
• ATP
• Cell imaging

A novel aminoquinoline functionalized norbornene (1) and its ring-opening metathesis polymerization (ROMP) copolymer P1 have been designed and synthesized. The polymer probe P1 can self-assemble nano aggregation in aqueous solution. The fluorescent experiments revealed that both 1 and P1 show a ratiometric fluorescence response toward Zn2+ over other mental ions in Tris-HCl buffer solution, with the polymer probe P1 shows a better photostability and higher binding affinity than that of the small molecular probe 1. Furthermore, the in situ formed P1-Zn2+ ensemble was successfully used as the secondary sensor for ATP. P1 is also successfully used for monitoring intracellular Zn2+ and ATP in living cells.

• 单位
  y; 南昌航空大学; 南昌大学