科研之友
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摘要
Photodynamic therapy（PDT） is a promising cancer therapy due to the evident advantages of a rapid curative effect,minimal or non-invasiveness,and circumvention of drug resistance.However,the hydrophobicity of photosensitizers and the hypoxic tumor microenvironment in solid tumors reduce the therapeutic effect of PDT immensely.Herein,we construct a programmable hybrid mesoporous silica nanoparticle/DNA nanogel（H-DNA nanogel） for enhanced PDT.The H-DNA nanogel is constituted with a virus-like mesoporous silica nanoparticle（VMSN） as the core to provide an appropriate nano-interface and a self-assembly programmable DNA hydrogel layer based on rolling circle amplification（RCA） as the shell.Two kinds of G-quadruplex structures inserted with a hemin and zinc phthalocyanine（ZnPc） photosensitizer are introduced into the H-DNA nanogel by base pairing.The two modules of G-quadruplex structure work as an oxygen supplement in the hypoxic tumor microenvironment and increase the yield of singlet oxygen,respectively.Our hybrid DNA nanogel system provides a modular platform for efficient cancer PDT and has great potential in the broader biomedical field.
