A comparison of Remdesivir versus gold cluster in COVID-19 animal model: A better therapeutic outcome of gold cluster

He, Zhesheng; Ye, Fei; Zhang, Chunyu; Fan, Jiadong; Du, Zhongying; Zhao, Wencong; Yuan, Qing; Niu, Wenchao; Gao, Fuping; He, Bo; Cao, Peng; Zhao, Lina; Gao, Xuejiao; Gao, Xingfa; Sun, Bo; Dong, Yuhui; Zhao, Jincun; Qi, Jianxun; Liang, Xing-Jie; Jiang, Huaidong^*; Gong, Yong^*; Tan, Wenjie^*; Gao, Xueyun^*

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广州医学院; 国家纳米科学中心; 北京工业大学; 中国科学院研究生院; 中国科学院; 1; y

摘要

While gold compound have been approved for Rheumatoid arthritis treatment as it well suppresses inflammatory cytokines of patients, no such treatment is currently available for COVID-19 treatment in vivo . We firstly disclose gold cluster yields better therapeutic outcome than Remdesivir in COVID-19 hamster treatments as it is armed with direct inhibition viral replication and intrinsic suppression inflammatory cytokines expression. Crystal data reveals that Au (I), released from gold cluster (GA), covalently binds thiolate of Cys145 of SARS-CoV-2 M-pro. GA directly decreases SARS-CoV-2 viral replication and intrinsically down-regulates NF kappa B pathway therefore significantly inhibiting expression of inflammatory cytokines in cells. The inflammatory cytokines in GA-treated COVID-19 transgenic mice are found to be significantly lower than that of control mice. When COVID-19 golden hamsters are treated by GA, the lung inflammatory cytokines levels are significantly lower than that of Remdesivir. The pathological results show that GA treatment significantly reduce lung inflammatory injuries when compared to that of Remdesivir-treated COVID-19 hamsters.

关键词

COVID-19 SARS-CoV-2 Gold cluster Viral replication Inflammatory cytokine