Time in range assessed by capillary blood glucose in relation to insulin sensitivity and β-cell function in patients with type 2 diabetes mellitus: A cross-sectional study in China

作者：Ye, Jingwen; Deng, Jiajin; Liang, Weiqiang; Luo, Haizhao; Mei, Wen; Liu, Lei; Wang, Mingzhu; Shu, Yi^*

来源：Journal of Diabetes Investigation, 2022, 13(11): 1825-1833.

DOI：10.1111/jdi.13876

• Insulin resistance
• Time in range
• beta-Cell function

Aims: This study investigated the association of capillary blood glucose (CBG)-assessed time in range (TIR) (3.9-10.0 mmol/L) with insulin sensitivity and islet beta-cell function. @@@ Materials and Methods: We recruited 455 patients with type 2 diabetes mellitus. Seven-point glucose-profile data (pre- and 120 min post-main meals, bedtime) were collected over three consecutive days. Plasma glucose and serum insulin concentrations were measured at 0, 60, and 120 min after a 100 g standard steamed bread meal test. The homeostasis model assessment of insulin resistance (HOMA-IR) and Matsuda index were computed to evaluate insulin resistance. The HOMA of beta-cell HOMA-beta) and the area under the curve between insulin and blood glucose (IAUC(0-120)/GAUC(0-120)) were used to estimate beta-cell function. @@@ Results: TIR was positively correlated with the 60 and 120 min insulin values, IAUC(0-120), the Matsuda index, HOMA-beta, and IAUC(0-120)/GAUC(0-120) (r(s): 0.154, 0.129, 0.137, 0.194, 0.341, and 0.334, respectively; P < 0.05) but inversely correlated with HOMA-IR (r(s): -0.239, P < 0.001). After adjusting for confounders, multinomial multiple logistic regression analysis revealed that the odds ratios (ORs) of achieving the target time in range (>70%) increased by 12% (95% confidence interval [CI]: 3-21%), 7% (95% CI: 1-14%), 10% (95% CI: 5-16%), and 45% (95% CI: 25-68%) for each 10 mIU/L increase in the 60 and 120 min insulin values, 10 unit increase in HOMA-beta, and unit increase in IAUC(0-120)/GAUC(0-120), respectively (P < 0.05). Nevertheless, the OR decreased by 10% (95% CI: 1-18%) for each unit increase in HOMA-IR (P < 0.05). @@@ Conclusions: Insulin resistance and islet beta-cell function are related to capillary blood glucose-assessed TIR.

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