Oxidative stress and inflammation caused by 1-tetradecyl-3-methylimidazolium tetrafluoroborate in rat livers

作者：Yuan, Huafei; Xu, Feng; Tian, Xingxing; Wei, Haiyan; Zhang, Rui; Ge, Yueyue; Xu, Hongmei^*

来源：Environmental Science and Pollution Research, 2022, 29(57): 86680-86691.

DOI：10.1007/s11356-022-21495-1

• Ionic liquids
• Rat
• Hepatotoxicity
• 1-tetradecyl-3-methylimidazolium tetrafluoroborate
• Oxidative stress
• Inflammatory response

The purpose of this study was to elucidate the mechanism underlying toxicity in the livers of male and female rats after treatment with 1-tetradecyl-3-methylimidazolium tetrafluoroborate ([C-14 mim]BF4, 0 [control], 12.5, 25, or 50 mg/kg) for 90 days. The results showed that [C(14)mim]BF4 exposure led to a high level of ROS and MDA in rat livers and the lower expression of Nrf2 and its downstream related antioxidant proteins. In addition, the expression of NF-kappa B p65 and the levels of inflammatory cytokines were upregulated in exposure groups rats' liver. After 30 days of cessation of exposure, the liver injury of rats in the 50 mg/kg exposure group was alleviated, and the above indicators were improved to varying degrees. The paper shows that [C(14)mim]BF4 could damage rat liver through oxidative stress and inflammatory pathway.