Transition-Metal-Free Disulfuration of Amides with Trisulfide Dioxides via Formation of Unaccessible S-S-N Bonds

作者：Yu, Yue^*; Chen, Jianxin; Huang, Mingzhou; Jiang, Yuhao; Zhou, Xianhang; Wang, Jinsong; Li, Jiaxin; Cao, Hua^*

来源：Journal of Organic Chemistry, 2024, 89(5): 3590-3596.

DOI：10.1021/acs.joc.3c02497

• REGIOSELECTIVE SYNTHESIS
• DISULFIDE
• REACTIVITY

Under transition-metal-free conditions, trisulfide dioxides were used as disulfurating reagents to react with a wide range of amides, affording various substituted N-disulfanyl amides in good yields. Furthermore, the gram-scale experiment has confirmed the practicability of this approach.

• 单位
  广东药学院; y