The effect of Hugu capsules on calcium related hormones and sex hormones in ovariectomized rats

作者：林泽苗; 钟佳贤; 贾欢欢; 吴玉娥; 陈珺; 曹祺; 曹克广; 李青南

来源：中国骨质疏松杂志, 2017, 23(1).

DOI：10.3969/j.issn.1006-7108.2017.01.020

• Hugu capsules
• Osteoporosis
• Serum hormone
• Uterus
• Ovariectomized rats
• Gonadal hormone

Objective To observe the effects of HG on hormones related to calcium metabolism, sex hormones and uterus in ovariectomized (OVX) rats.Methods Sixty female SD rats were distributed randomly into 6 groups:Sham group, OVX group,Xianlinggubao group (positive control) and HG low, medium and high dose groups (Sham, OVX, Pos, HG-L, HG-M, HG-H).After ovariectomy, from the next day the rats were ig administrated medicine continuously for three months.After euthanizing the experimental rats, uterus and serum were taken to study the effects of HG on uterus weight, serum 1,25 (OH)2D3, PTH, E2, P and T and its influence on endometrial tissue.Results Compared with the Sham group, OVX group's PTH (P ＜ 0.01) and T (P ＜0.05) increased;E2 (P ＜ 0.01) and P (P ＜ 0.05) decreased, uterine weight decreased significantly, and endometrial atrophy occurred.Compared with the OVX group, PTH were significantly lower in all doses of HG, but not in the Pos group;E2 increased significantly in the HG-L and HG-M groups, but not in the Pos group.P in the HG-L group decreased (P ＜ 0.05), but significantly increased in the Pos group.T in HG-L and HG-H groups was unchanged, decreased in the HG-M group, but increased significantly in the Pos group.There were not significant differences between each HG dose group and Pos group in uterine weight and endometrial tissue.Conclusion The effect of Hugu capsules on OVX rats was regulating PTH and E2 levels.This regulation is different from the mechanism of Xianlinggubao.Hugu capsules, as it increased estrogen levels but had little effect on the uterus.This study provided an experimental basis for promoting Hugu capsules in clinical treatment of postmenopausal osteoporosis.

• 单位
  广东药学院