Efficacy evaluation, active ingredients, and multitarget exploration of herbal medicine

作者：Ren, Jun-ling; Yang, Le; Qiu, Shi; Zhang, Ai-Hua^*; Wang, Xi-Jun^*

来源：Trends in Endocrinology and Metabolism, 2023, 34(3): 146-157.

DOI：10.1016/j.tem.2023.01.005

• TRADITIONAL CHINESE MEDICINE
• MASS-SPECTROMETRY METHOD
• FUNCTIONAL METABOLOMICS
• NATURAL-PRODUCTS
• DRUG DISCOVERY
• CHINMEDOMICS
• NMR
• CONSTITUENTS
• METABOLITES
• STRATEGY

Evidence shows that herbal medicine (HM) could be beneficial for the treatment of various diseases. However, complexities present in HM due to the unclear bio-active compounds, mechanisms of action, undetermined targets for therapy, and nonspecific features for metabolism, are currently an obstacle for the progression of novel drug discovery. Metabolomics could be a potential tool to overcome these issues and for the understanding of HM from a small-molecule metabolism level. The chinmedomics-based metabolomics method assesses the overall metabolism of organisms with a holistic view and shows great poten-tial for understanding metabolic pathways, evaluating curative effects, clarifying mechanisms, discovering active ingredients, and precision medicine. This re-view focuses on the efficacy evaluation, active ingredient discovery, and target exploration of HM based on metabolomics and chinmedomics.

• 单位
  广州中医药大学; 海南医学院