Metformin Exerts Anti-Neoplastic Effects via the Reactive Oxygen Species-Dependent Apoptosis and Inhibition of the AMPK/mTOR/Nrf2 Pathway in Papillary Thyroid Cancer

作者：Li, Jing; Zhu, Ziyi; Ye, Lizi; Wang, Zhiyang; Xiang, Guangda; Li, Shuguang^*; Yue, Ling^*

来源：Journal of Biomedical Nanotechnology, 2023, 19(5): 852-863.

DOI：10.1166/jbn.2023.3579

• Metformin
• AMPK
• mTOR
• Nrf2
• Apoptosis
• ROS

Papillary thyroid cancer (PTC) is a tumor associated with a high Nrf2 level. As a first-line antidiabetic medication, Metformin was recently shown antioxidants effects and inhibited nuclear factor erythroid 2-related factor 2 (Nrf2) expression in several malignant cells. However, whether Metformin regulates Nrf2 to inhibit PTC and the mechanism are inconclusive. We aimed to investigate Metformin's effects on oxidative disorders and its potential molecular mechanisms in PTC. Our results IP: 203 8 10920 On: Wed 23 Aug 2023 14:15:29 showed that Metformin increased Reactive Oxygen Spcies (ROS) acumlation in K1 cells. Mechanistically, Metformin Copyright: American Scientific Publishers significantly promoted ROS generation by inhibitingDeNrf2,ivered whichby Ingentainduced cellular apoptosis in K1 cells. Moreover, the AMP-Activated Protein Kinases (AMPK)/(the Mammalian target of rapamycin) mTOR signaling partially participates in the apoptosis process. The study showed that Metformin exerted an antitumor activity on K1 cells, via ROS generation and Nrf2 inhibition.

• 单位
  南方医科大学; 1