An Association between Inflammation and Cerebral Venous Thrombosis: A Retrospective Study

作者：Zhang, Xifang; Ding, Rui; Li, Haiyan; Liu, Yaqi; Ou, Weiyang; Hu, Jiangang; Tian, Yu; Wang, Qiujing^*

来源：Journal of Stroke & Cerebrovascular Diseases, 2021, 30(11): 106084.

DOI：10.1016/j.jstrokecerebrovasdis.2021.106084

• Cerebral venous thrombosis
• Inflammation
• Platelet
• lymphocyte ratio
• Neutrophil
• Systematic immune-inflammation index
• Monocyte
• high-density lipoprotein ratio

Objectives: Evidence is currently accumulating for the role of inflammation in cere-bral venous thrombosis (CVT). Neutrophil/lymphocyte ratio (NLR), platelet/lym-phocyte ratio (PLR), monocyte/high-density lipoprotein ratio (MHR), and systematic immune-inflammation index (SII) are easily obtainable indicators of sys-temic inflammations. However, there were few studies on the relationship between them and CVT. Therefore, we aimed to evaluate the connection between the occur-rence of CVT and the inflammatory markers described. Materials and Methods: The samples from 150 participants (including 90 CVT and 60 primary headaches as con-trols) with similar baseline characteristics were collected in this retrospective study. The NLR, PLR, MHR, SII and file records were employed to compare CVT patients with the control group. Results: The levels of NLR (3.93 [2.27, 7.87] vs. 1.65 [1.31, 2.06], P < 0.001), PLR (149.52 [98.39, 198.82] vs. 107.34 [83.31, 129.47], P < 0.001), SII (896.84 [559.89, 1591.87] vs. 382.45 [273.51, 520.92], P < 0.001) and MHR (0.51 [0.40, 0.64] vs. 0.41 [0.29, 0.53], P = 0.001) were significantly higher in the CVT group. After multivariate logistic regression analysis, the SII degree (13.136, [5.675, 30.407], P < 0.001) and MHR degree (2.620, [1.123, 6.113], P < 0.01) were found as independent predictors of CVT. Conclusions: NLR, PLR, SII, and MHR may be able to assist in the diagnosis of CVT which confirmed that inflammation played an important role in CVT.

• 单位
  中山大学; 南方医科大学