Synergetic fabrication of hybrid drug formulation using biodegradable tri-block copolymeric liquid nanoparticle delivery for gastric cancer chemotherapy

摘要

Hybrid-drugs chemotherapy is now one of the widely adopted treatments for cancer prevention with favorable diagnoses. This work has proposed compostable paclitaxel (PTX) and biotin (BT) PCEC nanomaterials (NMs) for the codelivery and to investigate the drug delivery mechanism's efficacy (PTX@BT-NMs) against gastric cancer cells in vitro and in vivo. The fabricated PTX@BT-NMs were 27.97 +/- 1.87 nm in size and had a less polydispersity index (0.156 +/- 0.030). PTX and BT were released slowly from the drug delivery without any burst impact. In addition, dose-responsive cytotoxic effects were observed for PTX@BT-NMs on SGC-791 cells with a higher mortality ratio than free drugs. According to a cellular uptake investigation, drug-loaded PCECs of polymeric liquid nanoparticles were considered better by cancer cells in vitro. To assess the in vivo antitumor activity, PTX@BT-NMs were administered intravenously injected to xenografted with SGC-791 cells. Substantial inhibition of tumor development was observed with extended survival time and decreased side effects with PTX@BT-NMs compared to free drugs (PTX + BT). Furthermore, compared to other therapy classes, PTX@BT-NMS care resulted in lower H&E and Ki67 expressions and improved TUNEL positive in cancer cells, indicating the chemotherapeutic efficiency of drug delivery system. Overall, the current investigation confirmed that DDS PTX@BT-NMs could be used to successfully combat gastric cancers in the immediate future.

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