Water-Soluble Metallo-Supramolecular Nanoreactors for Mediating Visible-Light-Promoted Cross-Dehydrogenative Coupling Reactions

作者：Han, Xin; Guo, Chenxing; Xu, Chen; Shi, Linlin; Liu, Binghui; Zhang, Zhe; Bai, Qixia; Song, Bo; Pan, Fangfang; Lu, Shuai; Zhu, Xinju; Wang, Heng^*; Hao, Xin-Qi^*; Song, Mao-Ping^*; Li, Xiaopeng^*

来源：ACS Nano, 2023.

DOI：10.1021/acsnano.2c10856

• self-assembly
• water-soluble metallo-supramolecular cages
• nanoreactors
• photochemical cross-coupling reactions
• supramolecular catalysis

Water-soluble metallo-supramolecular cages with well-defined nanosized cavities have a wide range of functions and applications. Herein, we design and synthesize two series of metallo-supramolecular octahedral cages based on the self assembly of two congeneric truxene-derived tripyridyl ligands modified with two polyethylene glycol (PEG) chains, i.e., monodispersed tetraethylene glycol (TEG) and polydispersed PEG-1000, with four divalent transition metals (i.e., Pd, Cu, Ni, and Zn). The resulting monodispersed cages C1-C4 are fully characterized by electrospray ionization mass spectrometry (ESI-MS), nuclear magnetic resonance (NMR) spectroscopy, and single-crystal X-ray diffraction. The polydispersed cages C5-C8 display good water solubilities and can act as nanoreactors to mediate visible-light-promoted C(sp3)-C(sp2) crossdehydrogenative coupling reactions in an aqueous phase. In particular, the most robust Pd(II)-linked water-soluble polydispersed nanoreactor C5 is characterized by ESI-MS and capable of mediating the reactions with the highest efficiencies. Detailed host-guest binding studies in conjunction with control studies suggest that these cages could encapsulate the substrates simultaneously inside its hydrophobic cavity while interacting with the photosensitizer (i.e., eosin Y).

• 单位
  广州大学; 江苏科技大学; 郑州大学; 西北大学