The relationship of vitam in D receptor gene and blood lead : a meta-analysis

作者：董秋颖; 赵春香; 陈福尊; 冀荷香; 张晓娜; 郝海燕; 李增敏; 李建国; 袁聚祥

来源：中华劳动卫生职业病杂志, 2016, 34(3).

DOI：10.3760/cma.j.issn.1001-9391.2016.03.011

• Receptors,calcitriol
• Lead poisoning
• Polymorphism,siagle nucleotide

Objective The correlation of vitamin D receptor (VDR) gene polymorphism and blood lead level had been in doult,which allowed us to write this article.Methods Relevant studies about the blood lead and VDR B/b gene polymorphism which published from 1979-2015,were searched in multiple bibliographic databases,such as:CNKI,Wanfang Database,PUBMED.Of the ten references selceted,three were divided into two groups which were classified as different researches,so there were thirteen studies in the meta-analysis.According to the level of blood lead,the studies were analyzed by three groups:normal group,low dose grou and high dose group.The analysis was performed by stata 12.0 software.Results The blood lead level of VDR B/ b genotype was significantly difference in all the three groups (P＜0.05),but there were apparent heterogeneity between normal group and low dose group (P＜0.05,I2=84.2％;P＜0.05,I2=88.9％),except the high dose group (P＞0.05,I2=12.7％);after adjusted,all showed no heterogeneity,and the results were still the same.Conclusion The genotype of VDR may be correlated with blood lead,and the levels of blood lead varied with different genetypes.

• 单位
  河北医科大学