Uncovering the extensive trade-off between adaptive evolution and disease susceptibility

作者：Tang, Ji; Huang, Maosheng; He, Sha; Zeng, Junxiang; Zhu, Hao^*

来源：Cell Reports, 2022, 40(11): 111351.

DOI：10.1016/j.celrep.2022.111351

• NATURAL-SELECTION
• ASSOCIATION
• ADAPTATION
• RESISTANCE
• VARIANTS
• INSIGHTS
• GENE

Favored mutations in the human genome may make the carriers adapt to changing environments and lifestyles but also susceptible to specific diseases. The scale and details of the trade-off between adaptive evolution and disease susceptibility are unclear because most favored mutations in different populations remain unidentified. As no statistical test can discriminate favored mutations from nearby hitchhiking neutral ones, we report a deep-teaming network (DeepFavored) to integrate multiple statistical tests and divide identifying favored mutations into two subtasks. We identify favored mutations in three human populations and analyzed the correlation between favored/hitchhiking mutations and genome-wide association study (GWAS) sites. Both favored and hitchhiking neutral mutations are enriched in GWAS sites with population-specific features, and the enrichment and population specificity are prominent in genes in specific Gene Ontology (GO) terms. These provide evidence for extensive and population-specific trade-offs between adaptive evolution and disease susceptibility. The unveiled scale helps understand and investigate differences and diseases of humans.

• 单位
  南方医科大学; 广东药学院