Nomogram Based on Preoperative Fibrinogen and Systemic Immune-Inflammation Index Predicting Recurrence and Prognosis of Patients with Borrmann Type III Advanced Gastric Cancer

作者：Wang, Hao; Yin, Xin; Ma, Keru; Wang, Yufei; Fang, Tianyi; Zhang, Yao; Xue, Yingwei^*

来源：Journal of Inflammation Research, 2023, 16: 1059-1075.

DOI：10.2147/JIR.S404585

• gastric cancer
• Borrmann classification
• fibrinogen
• systemic immune -inflammation index
• recurrence
• nomogram

Background and Objectives: The prognosis is known to differ significantly among advanced gastric cancer (AGC) with Borrmann type III. This study aimed to evaluate the prognosis of these patients more individually. Methods: We selected 542 AGC patients with Borrmann type III. We used the receiver operating characteristic curve to analyze the cutoff values of inflammation indexes, and used Kaplan-Meier and Log rank tests to analyze recurrence-free survival (RFS) and overall survival (OS). The independent risk factors for recurrence and prognosis were analyzed by Cox proportional hazards regression model. The nomogram models were constructed by R studio. Results: Patients with high preoperative fibrinogen (F) and systemic immune-inflammation index (SII) levels had worse RFS and OS and higher risk of postoperative locoregional recurrence, hematogenous metastasis and lymph node metastasis. F and SII can combine with different clinicopathological features (all P<0.05) to construct nomograms to predict 5-year recurrence and prognosis, which both were superior to pTNM stage alone. Conclusion: The nomogram models based on F and SII can evaluate AGC with Borrmann type III postoperative recurrence and prognosis.

• 单位
  哈尔滨医科大学